The problem of drug abuse has a global impact because it has an impact on addiction and the difficulty of getting healing. Drug abuse carried out continuously by an individual will affect the function of thinking, feeling and behavior of the person who uses it. The aim of the study was to influence logotherapy to control depression in patients with drug abuse at the Kassi Kassi Health Center and Jumpandang Baru Health Center. Quasi experimental research design with pretest and posttest control group design. Population: all drug abuser patients at the Methadone Maintenance Therapy Program in Kassi Kassi Health Center and Jumpandang Baru Health Center were 40 respondents. The research instrument used the Beck Depression Inventory Scale II questionnaire. Univariate data analysis included the values of frequency, mean, ± SD, and min-max values. Bivariate data analysis used paired t-test, paired t-test (independent t-test), and Mann-Whitney test. The results showed that there were differences in depression scores before and after administration of logotherapy in the intervention group because the p value was 0.001 <0.05. The results of the analysis also showed that there were differences in depression scores in the intervention group and the control group, because the value of p value in the first posttest score, the second posttest score, and the posttest mean score was 0.001 <0.05. Conclusion: There were significant differences in depression scores between the intervention group and the control group after the implementation of logotherapy. There were also significant differences in depression scores in the intervention group before and after the implementation of logotherapy. Thus, there is an effect of logotherapy to control depression in patients with drug abuse.