Aging has resulted in dramatic effects on body organs and development of metabolic diseases with suspected origin from defects of gonads. The research is to examine the aging related changes of cytological framework of the pituitary adenohypophysis and demonstrate the antiaging effects of supplementation of whey. Eight and 30-months old rats were divided into two main groups with or without whey supplementation (n=4). Whey supplementation was carried out every other day for two months. This was accompanied by euthanization and dissection of pituitary gland, fixation in phosphate buffered osmium tetraoxide and processed for transmission electron microscopic examination. Whey supplementation of 8 moth-old rats maintained the secretory function of somatotroph and gonadotroph cells. However, old rats (30 month old) possessed edematous lesions in sommatotroph and gonadotroph cells with degranulation of secretory granules. Congestion of blood capillaries and accumulation of fat globules were observed. Whey supplementation to old rats improved the cytopathological changes and restored the accumulation of secretory granules. The capacity of whey supplementation to restore the secretory function of sommatotroph and gonadotroph cells that are responsible for the secretion of growth hormone and testosterone and follicle stimulating hormone that decrease the aging related development of diseases.