Experiment was conducted in field under organic conversion, to determine the effect of four rates of indigenous bio-pesticides on root-knot disease, growth and yield of Amaranthus cruentus. The trial was laid out in a Randomized Complete Block Design. The experiment consisted of 16 treatments replicated three times with the dimension 3 m x 4 m. Seeds were first planted in the nursery bed to raise healthy seedlings for transplanting four weeks after emergence. Pre-plant herbivorous nematode population was determined prior to seedling transplanting. The biopestices were applied at the rate of 0, 100, 125 and 150 ml/16 Litre of water by spraying them between 6.30 and 7.30 am biweekly as foliar and soil applications. Growth parameters and nematode population were taken two Weeks After Biopesticide Applications (WABA) and sustained bi-weekly until 8 WABA. Nematode census was again determined 60-66 Days after Transplanting. Data obtained were subjected to Analysis of Variance using Statistical Analysis System (SAS) version 10.2 and statistically significant treatment means were separated using the new Duncan Multiple Range Test at 5% level of probability. The four tested bio-pesticides suppressed (p ≤ 0.05) nematode population and number of galls with attendant better (p ≤ 0.05) growth performance compared with the control (unsprayed plots). BIO183 and BIO184 at 100 ml were the most efficacious. It is recommended that BIO181 at 100 ml can be further verified on farmers’ fields for possible adoption for root-knot nematode population management in A. cruentus