Coronavirus is now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the resulting disease is called coronavirus disease 2019 (COVID-19). The World Health Organization (WHO) declared the novel coronavirus outbreak a global pandemic in March 2020. Despite rigorous global containment and quarantine efforts, the incidence of COVID-19 continues to rise, with more than 2,973,347 laboratory-confirmed cases and over 206,018 deaths worldwide. Currently, no specific medication is recommended to treat COVID-19 patients. However, governments and pharmaceutical companies are struggling to quickly find an effective drug to defeat the coronavirus. In this review article we summarize the usefulness of C-reactive protein as positive phase protein and albumin as negative phase protein as investigator of mortality for COVID-19 patient. Relying on C-reactive protein level to albumin level ratio over either albumin or C-reactive protein alone. Ferritin level also may be good predictor for morbidity and mortality but it is affected by iron overload and existing stress condition in COVID-19 patient result in deviation in ferritin level to be higher than expected. Ratio of ferritin to albumin is useful in determining the mortality, risky, diagnostic, following, determination in many illnesses. In our article we will focus in the possibility of the clinical usefulness of C-reactive protein and ferritin level to albumin ratios in triaging, stratifying, diagnosis, following and assessing COVID-19 infected hospitalized patients.