The pandemic coronavirus disease which has started in 2019 (COVID-19) in Wuhan China, is the major humanity concern nowadays. COVID-19 causes Acute Respiratory Distress Syndrome (ARDS) after cytokine storm is pursuing and elderly are the most susceptible. Efforts are made to find a vaccination or a treatment for COVID-19 infection. Due to lack of adequate evidence, no anti-SARS-CoV-2 drug or vaccine has been approved officially, yet. Drug repurposing is at the essence of this battle and since Minocycline has a preferable safety profile and high tolerability, it can be a great tool to the treatment regimens applied. Minocycline has demonstrated antiviral and immunomodulatory activity that is independent of its antibacterial activity. Additionally, the proposed combination with Azithromycin enhances the anti-inflammatory effects of Minocycline which is necessary for a fighting off an excessive cytokine storm response. Some researchers reported effective therapeutic options. On the other hands, there use was limited either because of severe side effects or high cost. In this review article we shall go over recent researches that would support the usage of Minocycline in combating the Coronavirus (SARS-CoV-2) outbreak. Further efforts are require to developing the safest and most effective approach to decrease mortality rate in suspected population and severe case.