Abstract: Introduction: Gall bladder carcinoma was first described in 17th century, Incidence of gall stones increased over time and so is the incidence of carcinoma gall bladder. Still tumor remains characterized by an unfavourable prognosis due to silent progression of the clinical course and limited knowledge of its aetiology and poor scientific capability for epidemiological forecasting. The incidence of GBC varies in different parts of the world. Overall incidence ranges from 0.11/100000 to 10.6/100000 in different cancer registries worldwide [1]. Our study is an attempt to establish relationship between CA19-9, CEA with metastasis, operability and resectability. Methods: Study type is prospective cohort study. It was carried out among newly diagnosed, intraoperative and referred cases of carcinoma gall bladder at IGMC Shimla. All newly diagnosed, intraoperative and referred cases of carcinoma gallbladder were recruited in the study. The total duration of study was of one year. Result: Female sex in their sixties are most commonly involved. Gall stones are associated with 56% of the patients. In CECT abdomen most common finding is of metastatic disease. Adenocarcinoma is most common HPE finding. CEA and CA19-9 both show direct relation with metastasis and in operability and inverse relation with resectability however results were not statistically significant. Conclusion: Gall bladder carcinoma incidence is increasing with time but measures to tackle it not evolving at the desired speed. CEA and CA19-9 showed some promising results but still a larger study needed to establish relation between them and the factors mentioned above. Primary prevention will arrive once high risk environmental toxins and genetic abnormalities are clearly identified and further studies should be dedicated for its early diagnosis and treatment.