Background: Everyman has a prostate; but every prostate doesn’t have to make a man’s life miserable. The prostate gland is the ‘powerhouse’ of every man. Data from the Ghana Health Service shows that 3052 cases of cervical cancer were recorded in 2015 out of which 1556 died, representing 51 percent, breast cancer also recorded 2260 cases with 1021 deaths, representing 45 percent, prostate cancer has 912 cases being recorded with 680 deaths, representing 75 percent. This paper discusses the prostate cancer situation in Ghana compared to top gynecological cancers such as Breast and Cervical Cancer. Method: A review of the cancer mortality and incidence rate were conducted using search engines such as Google, PubMed with keywords such as prostate cancer, Breast and Cervical cancer. Result: The fatality rate result appears outrageous for prostate cancer in Ghanaian men toppling Breast and Cervical cancer with only 25% of men diagnosed with the disease survived in Ghana annually. Conclusion: Urgent National attention should be paid to the fatality rate in Ghana on prostate cancer. Awareness and national screening programs should be initiated early as possible with government support towards men’s Health.