Objective：To observe the therapeutic effect of continuous renal replacement therapy (CRRT) in the kidney intensive care unit (kicu) of our hospital, to explore the opportunity of CRRT treatment, and to observe the efficacy of kicu in the treatment of critical patients. Methods: 190 critical patients who needed CRRT in ICU and KICU of our hospital were analyzed retrospectively, from January 2017 to December 2019. The above patients were divided into 72 cases of acute renal injury (AKI) and 118 cases of chronic kidney disease (CKD).At the same time, patients with AKI and MODS were divided into two groups according to the creatinine value of 355umol/L. The patients with creatinine value < 355umol/L were in the low creatinine group, and the patients with creatinine value ≥ 355umol/L were in the high creatinine group. The outcome of each index in the two groups was compared after CRRT treatment Results: CRRT can significantly reduce the white blood cell (WBC) count and procalcitonin (PCT) in patients with AKI and CKD, but there is no significant positive result between the two groups according to the creatinine value of patients with AKI and MODS.In addition to the known function of detoxification and drainage, CRRT can significantly reduce the circulating inflammatory mediators and play an anti-inflammatory and immunomodulatory role. Conclusions: Creatinine value is a classical index of renal function, but it can not independently evaluate the time of CRRT treatment. It should be combined with age, mechanical ventilation, organ dysfunction, end-stage disease and other comprehensive evaluation. KICU plays an important role in the treatment of critical patients.