Background: Spondiasdulcris has diverse traditional medicinal uses in its fruits, leaves and bark in different parts of the world. It is useful for burns and wound healing, remedy for diarrhea, anti-diabetic, antihypertensive and the inner bark is used to treat cough and fever. Objective: The aim of this study was to determine the effects of aqueous bark extracts of unripe Spondias dulcris on plasma glucose, triacylglycerol concentrations and weight in normal albino rats as well as histopathological examination of the liver, hearts and kidney sections of the rats. This was done with a view of understanding the possible role of this plant in the treatment of diabetes mellitus. Materials and Methods: The test groups were administered a dose of the extract (2ml/kg body weight) twice daily in addition to growers mash while the control group was exposed to only grower’s mash and distilled water. The plasma glucose and triacylglycerol concentrations were measured by spectrophotometry. Both groups were weighed on the weighing scale on test days up to the 28th day after which the animals were sacrificed and histological examination was done. Results: The result showed significant (p<0.05) reduction in plasma glucose and triacylglycerol in the test group when compared to the control. The histological report showed that the aqueous extract of Spondias dulcris was neither cardiotoxic, hepatotoxic nor nephrotoxic. Conclusion: Conclusively the aqueous bark extract of Spondias dulcris could have therapeutic effects by its anti-diabetic and hypolipaemic effects in a number of metabolic syndromes including diabetes mellitus in humans.