Background: This research work is carried out to evaluate the anti biotic sensitivity profile of bacterial nasal isolates from Delta State University students. Materials and Methods: To determine this, nose swabs of were obtained from two hundred (200) students in site 2 and site 3 of Abraka campus of Delta State University and were immediately cultured and identified using bacteriological methods according to the laid down procedure. Antibiotic sensitivity test (AST) was performed on their sensitivity pattern. Results and Discussions: Of the 200 nose swabs collected, 94 distinct colonies were obtained and analyzed. Fifty (54) were identified to be Gram-positive organisms, of which 19 (41.5%) were identified to be Staphylococcus aureus , 13 (13.8%) to be Stahpylococcus epidermis and 2 (2.1%) to be Staphylococcus species) while 40 isolates were identified to be Gram-negative organisms, (of which 3(3.2%) were identified to be Esherichia coli, 1 (1.06%) to be Proteus species, 5( 5.32%) to be Enterobacter spp, 24 (25.553%) to be Citrobacter spp, and 7(7.45%) to be Klebsiella species. Amongst the Gram-negative antibiotics susceptibility was highest with the Streptomycin, levofloxacin, ampiclox, Chloramphenicol and rifampicin, but lowest with ciprofloxacin and erythromycin. Amongst the Gram –negative antibiotics, susceptibility was highest with Streptomycin, Ofloxacin, Trimethoprim/ sulmethoxazole and perfloxacin but lowest with augmentin and nalidixic acid. Conclusion: It should be noted that the presence of different species in the nares is in accordance with the fact that microorganisms are ubiquitous meaning it can be found everywhere in nature.