EAS Publisher | Biochemical and Histopathological Studies on the Role of Selenium Nanoparticles and Selenium Oxide against Chemically-Induced Diabetes in Male Rats

Biochemical and Histopathological Studies on the Role of Selenium Nanoparticles and Selenium Oxide against Chemically-Induced Diabetes in Male Rats

DOI : https://doi.org/10.36349/easmb.2020.v03i07.003

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The study was designed to evaluate the effect of the biologically produced selenium nanoparticles (SeNPs) against streptozotocin (STZ) induced diabetic using adult male rats. Sixty mg/kg of STZ was injected in rats to induce diabetes. Animals either treated with SeNPs, selenium oxide (SeO2) or a mixture of SeNPs and SeO2 at a dose level of 0.1 mg Se/kg body weight/day. The results demonstrated that selenium or its nano form has antioxidant and catalytic effect and both were able to prevent the histological injury in pancreatic and liver tissues of rats. This study suggests that Se and SeNPs can ameliorate cellular damage resulting in diabetes and has a protective effect to minimize the risk of diabetic complications which may be attributed to its free radical scavenging effect

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