Occupational contact dermatitis (OCD) is one of the most common occupational skin diseases. Occupational contact dermatitis has been observed to have a high risk of occurrence among the blue collar workers at workplace. Occupational contact dermatitis regularly causes high levels of worker morbidity. The incidence rate was confirmed cases was 20.5 per 100,000 workers. The 1-year period prevalence rate was 34.5 per 100,000. Hence a study is aimed to assess the clinical symptoms and associated risk factors of occupational contact dermatitis among leather shoe production industry workers. METHODS: A descriptive research design was used in this study. The total study sample was 100 workers who work in leather shoe production industry. The sample were selected using purposive random sampling. Modified Nordic Occupational Skin Questionnaire NOSQ-2002 checklist to assess the clinical symptoms and self-structured questionnaire was used to assess the associated risk factors of Occupational Contact Dermatitis. RESULT: The study concludes that most of them have redness frequently 48(48%), dry skin frequently (40%), burning frequently 50(50%), sometimes they have blisters 39(39%), most of them have itching sometimes 67(67%), majority of them have pain/aching sometimes 59(59%). The major risk factors that cause occupational contact dermatitis (OCD). Contact with leather is 20%, no protective gloves used is 20%, working hours is greater than 8 hours is 18%, contact with adhesives/glues is 16%, contact with liquid soaps, shampoos is 14%, frequency of hand washing is less than 5 times per day is 12%.