EAS Publisher | Impairment of Hepatic, Cardiac and Lung Tissues in Aspartame Treated Male Wistar Albino Rats

Impairment of Hepatic, Cardiac and Lung Tissues in Aspartame Treated Male Wistar Albino Rats

DOI : https://doi.org/10.36349/EASMS.2020.v03i02.003

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Aspartame is widely used artificial sweeter as well as in foods products such as soft drinks, hot chocolate, candy, as well as some vitamins and sugar-free cough drops. There is no available work concerned hepato-,cardio-and lung toxicities. The present studies focused on analysis the aspartame associated alterations of the mentioned organs. Fourteen male albino Wistar albino rats weighing approximately 100 gram body weight. They were divided into two main groups. Control and aspartame-treated groups (80mg/kg body weight every other day for 4 weeks). At the end of treatments, animals were sacrificed and liver,heart and lung were dissected and processed for histological investigation and immunohistochemistry of caspase 3. The present findings showed focal collection of inflammatory cells associated with damaging liver, myocardium and alveolar cells. Interstitial fibrosis of the alveoli was detected. Immunohistochemistry of caspase 3 revealed increased increased immunostaining manifesting cell death. Finally the authors concluded that aspartame-treatment led to cardio-,hepato and lung toxicity that must be controlled during administration.

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