Introduction: Job satisfaction is one of the most important factors in job success, especially in nurses and hospital staff who play a significant role in promoting community health as human resources. Therefore, this study was conducted to evaluate the job satisfaction of emergency staff at Shiraz public hospitals. Methods: This cross-sectional study was carried out on 400 nurses working in the emergency departments of 5 hospitals in Shiraz. The sampling from the emergency departments was done randomly. The data were collected using the JDI questionnaire (Job Descriptive Index), and the t-test and ANOVA were also used to analyze the data. Results: 274 individuals in this study (68.5%) were female and 211 ones (52.8%) were married. There was no significant relationship between job satisfaction and gender, employment status, organizational position, and marital status (p> 0.05). According to the ANOVA results, there was a significant relationship between job satisfaction and educational level (p = 0.006), work experience (p = 0.014) and income (p = 0.003). Conclusion: Based on the results of the present study, the individuals with higher work experiences, higher education and higher income had higher job satisfaction as well.