The Bundelkhand region of central India is different geographically, socially and economically. It is a semi-arid plateau area. This region is marked by extremes of temperature. The climatic and geographical conditions in this region favours the development of skin diseases. Studies have shown that several variants of psoriasis are developed in this region. Aims: The aim of this present study was to investigate the immunohistochemical expression of VEGF and Survivin in psoriatic skin and to detect their role in the pathogenesis of Psoriasis so that therapy could be targeted against suvivan and angiogenesis in the treatment of psoriasis patients. Settings: A retrospective case control study in a tertiary referral centre. Material & methods: A total of 54 cases were taken who visited the Dermatology OPD from January 2016 to october2017. These cases were diagnosed as Psoriasis after histopathological examination. Each case was subjected to general examination, H&E staining (Culling 1975) and immunohistochemistry with VEGF and Survivin. Results: Maximum 37% cases shows cytoplasmic VEGF staining in epidermis, dermis & blood vessels. 13% cases shows VEGF staining in epidermis and blood vessels. 30 cases showed nuclear and cytoplasmic SURVIVIN staining in epidermis. 26 cases shows Survivin staining in epidermis + sweat glands .The value of |Z| obtained is 5.04216 and p<0.0001 implies that there is high significant difference between Psoriasis studied with age and duration of Psoriasis. Conclusion: Over expression of survivin in psoriasis denotes its important role in the apoptosis suppression as a possible mechanism in the pathogenesis of Psoriasis so that survivin targeted therapies can be benifited in the treatment of psoriasis.