Among all the neurological diseases, the cerebrovascular clearly rank the first in frequency and importance. At least 50% of the neurological disorders in a general hospital are of this type. Stroke, after heart disease and cancer is the most common cause of death in tertiary health center. Various studies have shown that uric acid can result in endothelial dysfunction which can lead to vascular disease. An association between SUA and inflammatory markers has also been discovered moreover therapeutic modalities with a SUA lowering potential have been shown to reduce CV disease morbidity and mortality.Aim: To study the role of Serum Uric Acid (SUA) in acute ischemic stroke and the association between SUA and other risk factors namely hypertension, diabetes mellitus, CAD and adverse lipid profile.Methods: The present study was conducted in Navodaya Medical College, Raichur over a period of one year. 100 patients of first ever in life time acute ischemic stroke were included. The blood samples were taken within 24 hrs of onset of stroke and sent for detailed biochemical analysis. The patients were further evaluated for risk factors such as hypertension, diabetes, coronary artery disease, adverse lipid profile, smoking and alcoholism.Results: Out of 100 patients of acute ischemic stroke included in our study, 50 were males and 50 were females. The mean serum uric acids level in our study of 100 patients with acute ischemic stroke was 5.51 mg/dl and the overall mean age for stoke in our study was 60.57. The age distribution showed that the majority of our patients i.e. 61% were above 50-69 years of age. Thus our study supports the fact that prevalence of stroke is more in elderly people and it is associated with raised serum uric acid levels with upper limit of normal value. Hypertension constitutes major risk factor with 65% study population being hypertensive. Diabetes Mellitus ranks second as risk factor, constitutes 51% of study population.