Drug availability is a crucial part of patients healing, especially for chronic patient such as hypertension patients. Studies in the area of drug supply for JKN patients with hypertension was lacking. The objective of this study were to explore the causes of drug shortage through the perspective of the drug production and the hospital’s realization process of Drug Needs Plan (RKO). We interviewed respondents from 7 manufacturers the winner of JKN drug tender, consisted of 2 government pharmaceutical manufacturers (BUMN), 2 international pharmaceutical manufacturers and the last 3 national private manufacturers. The involved informant were those who directly deal with the production process of JKN drug hypertension. The result of this research data collection was processed in content analysis.Result shown that the process between JKN drug and non-JKN drug production were similar. If the raw and the packaging materials were readily available, the manufacturer takes a month to produce the drug, otherwise the manufacturer takes three up to six months. The manufacturing process were done together in one production time. Before starting to produce drug, the manufacturer must collected several order form hospitals to fulfill one production time. The driving factors of JKN drug production were production of the same type of drug in one production time and high quantity of drug to be produced (high demand). The hurdle of JKN drug production short period between the number of production quantity and the production process, procurement beyond e-purchasing system, instability of foreign exchange rate, 2 years expired date regulation and availability of raw materials.In conclusion, according to respondents the quality of JKN and non-JKN drug were similar, there was no differences in the production process. The duration of production times depends on the raw materials availability in manufacturer was the major problem caused drug shortage in the hospital.