Background: Nomophobia literally means no mobile phobia that is the fear of being out of mobile phone contact. The use of mobile phones has now increased worldwide during the last decade. Hence this study was carried out to evaluate mobile phone dependence among the study subjects. Methodology: The present study is a cross-sectional study conducted amongst 246 M.B.B.S. students from Govt. Medical College. A pre-designed and pre-tested questionnaire was used to study mobile phone dependence among the study subjects. The individual responses were noted and the data was analysed using statistical software. Results: The study population comprised of 138(56.1%) males and 108 (43.9%) females. Majority of students were of age group 19-22 years. Overall 21.95% were found to be nomophobes, among them 14.6% were males and 7.3% were females. All students were having mobile phones, 75.6% had installed games. 42.68% get stressed/ anxious when their mobile run out of battery and 41.5% keep mobile switched off or silent when they go to sleep. 40.24% students would keep mobile phone on table in front of them when out for dinner and 35.4% use mobile while having food. 36.6% get anxious if they won’t get an instant response to an SMS and 20.73 % always keep seeing mobile/waiting for a message or call to come.12.2% students answered that the thought of turning off their mobile would send them in shiver. While attending classes 12.2 % of students don’t switch off/ keep in silent mode and 10.97% receive call. Conclusion: The results of the study are suggestive of mobile phone dependence and most of the study subjects knew that mobile use could be an addiction. As nomophobia is an emerging problem, more studies are required to assess the real problem and to take the appropriate steps. The nomophobic students were convinced on the harmful effects of using mobile phones.