Antacids are commonly used as over - the - counter (OTC) drugs or prescribed medications. Some antacid products may neutralize more acid in the stomach than others. The ability of an antacid to neutralize acid is expressed as its Acid Neutralizing Capacity (ANC). This study was undertaken with the objective of assessing the quality of different brands of antacid tablets. The assessment parameters included the evaluation of uniformity of weight, uniformity of thickness, crushing strength, friability, as well as the ANC (using pH and titrimetric method), which is easy to use, accurate, reproducible, simple, and inexpensive. The study revealed that all the brands complied with the compendia specification for uniformity of weight and friability. The acid neutralizing capacity of the brands were in the order Brand E > Brand D > Brand C > Brand A > Brand F > Brand B > Brand G. The average final pH of the mixture of Antacid and acid after 10 minutes is as follows: Brand E 8.30, Brand D 7.46, Brand C 7.37, Brand A 6.67, Brand F 6.35, Brand B 6.02 and finally Brand G 5.88. It can be concluded from the study that two of the brands (D and E) evaluated in this study could be regarded as being of highest quality with Brand E having the highest ANC value. This study could help prescribers to make informed choices for their patients. The titrimetric procedure used in this study is simple, inexpensive, easy to use and could be used in routine monitoring or periodic evaluation of the quality of Antacid tablets, especially in the absence of high technology equipment that are not easily available in most developing countries.