Identification of gaps in stroke related knowledge among at risk individuals is vital to effective stroke prevention measures. This study aimed to assess the awareness of self risk of stroke and superstitions regarding stroke, among persons with sickle cell anemia in Calabar, Nigeria. We conducted a survey on eighty three members of the sickle cell support club, in Calabar, diagnosed with HbSS hemoglobinopathy. Univariate, bivariate and binary logistic regression were used to analyze data generated with a self-administered questionnaire on awareness of self risk of stroke conferred by inherited HbSS hemoglobin, held superstitions regarding stroke, knowledge of stroke symptoms and their opinion of where stroke is best managed. 34.9% of the respondents were unaware of their increased stroke risk. 27.7% of them believed that stroke is caused by witchcraft or voodoo. Four fifths of those who had up to tertiary level of education did not agree that stroke is caused by voodoo, compared to two thirds of those with less education (p=0.047). 65.1% of the respondents possessed poor awareness of stroke symptoms. High level of education (p=0.04) and recognizing hospital as where stroke is best managed (p= 0.047) were identified predictors of awareness of increased self-risk of stroke. Many of the respondents were unaware of their increased stroke risk, believed voodoo to be a cause of stroke, and unable to correctly identify stroke symptoms. Improved population literacy rate and tailored public health education would help to address identified stroke related knowledge gaps and erroneous beliefs.