Introduction: Lung resection is a surgical procedure to remove a lung lobe or a complete lung, usually following tumor or infectious diseases. It is often at risk of respiratory and non-respiratory complications that can result in a significant morbidity and mortality. Our objective was to describe the épidémio-clinical and outcomes of non-respiratory complications after lung resection. Method: We performed a descriptive retrospective study in the department of thoracic surgery of the CHU JRA over a period of 07 years, from January 2009 to December 2016. Patients who had undergone a major lung resection of non-traumatic origin were included. Results: Of the 88 patients retained, 76.14% were male, with a sex ratio of 3.19. The mean age was 48 years with extremes of 23 and 83 years. The main indications were infectious, lung aspergilloma (51.14%) and malignant tumor (30.68%). The most common procedures were lobectomy (62.5%) and pneumonectomy (26.13%), predominantly on the right side (78.40%). There were 84.09% of patients with post-operative complications, including 25% cardiovascular, 21.59% parietal, 21.59% infectious, 19.31% neurological and 1.14% digestive. These complications were mostly grade II according to the Clavien and Dindo classification (32.43%). The mortality rate was 11.36%, increasing with age and male predominance. Conclusion: Non-respiratory complications after lung resection are very common and often unfavourable. Improvement of the non-respiratory morbidity and mortality after lung resection requires early management before, during and after surgery.